Schwann cell proliferation in vitro is under negative autocrine control.
نویسندگان
چکیده
منابع مشابه
Schwann cell proliferation in vitro is under negative autocrine control
In healthy adult peripheral nerve, Schwann cells are believed to be generally quiescent. Similarly, cultures of isolated rat sciatic nerve Schwann cells hardly proliferate in serum-supplemented medium. The possibility that Schwann cells negatively regulate their own proliferation was supported by the demonstration that conditioned media from Schwann cell cultures inhibited the proliferation of ...
متن کاملStudies of Schwann Cell Proliferation
In this paper the stimuli for and pattern of Schwann cell proliferation are defined under various experimental conditions . We used a tissue culture system in which fetal rat dorsal root ganglia, treated to eliminate contaminating fibroblasts (Wood, P., 1976, Brain Res. 115:361-375), appear to recapitulate many aspects of the developing peripheral nervous system . We observed that : (a) prolife...
متن کاملStudies of Schwann Cell Proliferation
In the preceding paper (Salzer et al ., 1980, J. Cell Biol. 84:753-766), evidence was presented that a neurite membrane fraction could be used to stimulate Schwann cell proliferation in culture . In this study, we present evidence that the mitogenic signal by which intact neurites or neurite membranes stimulate Schwann cell proliferation is located at the neurite surface . This conclusion is ba...
متن کاملStudies of Schwann Cell Proliferation
In this paper the stimuli for and pattern of Schwann cell proliferation are defined under various experimental conditions . We used a tissue culture system in which fetal rat dorsal root ganglia, treated to eliminate contaminating fibroblasts (Wood, P., 1976, Brain Res. 115:361-375), appear to recapitulate many aspects of the developing peripheral nervous system . We observed that : (a) prolife...
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Background: Peripheral nerve injury (PNI) is a common condition that compromises motor and sensory functions. Peripheral nerves are known to have regenerative capability and the pineal hormone, melatonin, is known to aid nerve regeneration. However, the role of Schwann cells and the pathways involved remain unclear. Thus, the aim of this study is to identify the effects of melatonin on Schwann ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1990
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.111.6.2663